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{"sheet":"Invulblad en resultaten","index":1,"n_rows":34,"n_cols":24,"rows_kept":34,"cut":false,"hidden":false,"merged":[[0,22,0,23],[6,8,6,12],[6,13,6,14],[7,13,7,14],[7,8,7,12],[0,20,0,21]]}
[null,"GGD Rekentool Luchtkwaliteit & Gezondheid - Invulblad en resultaten"]
[]
[null,"Vul in het aantal bewoners :",null,null,"2013438","Check op representativiteit!"]
[]
[null,"Vink de stoffen aan waarmee je wilt rekenen en vul vervolgens"]
[null,"de blootstelling in (gebruik de schuifbalk of pijltjes)",null,null,null,null,null,null,"Vroegtijdige sterfte in dagen ",null,null,null,null,null,null,null,"Daling longcapaciteit kinderen 0-18 jaar (FEV1) in % (PM2,5 en NO2)"]
[null,null,null,null,{"$f":"IF(AND(B8=FALSE,B11=FALSE),\"onjuiste invoer, of PM10 of PM2,5 of beide aanvinken\",IF(B8=TRUE,$E$8*0.1,E11/0.52))","v":15},null,null,null,"One-pollutant model ",null,null,null,null,"Two-pollutant model"]
[null,true,"PM10",null,150,null,null,null,"(PM2,5 en NO2: Hoffman, 2022; PM10: Hoek, 2021)",null,null,null,null,"(RIVM, 2023)"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"ROUND(Rekenblad!B26*100,1)","v":1.6}]
[null,null,null,null,null,null,null,null,{"$f":"Rekenblad!B36","v":369},null,{"$f":"Rekenblad!B35","v":189},null,{"$f":"Rekenblad!B37","v":218},null,{"$f":"Rekenblad!B31","v":351},null,null,{"$f":"ROUND(Rekenblad!B27*100,1)","v":1.1000000000000001}]
[null,true,null,null,{"$f":"IF(AND(B8=FALSE,B11=FALSE),\"onjuiste invoer, of PM10 of PM2,5 of beide aanvinken\",IF(B11=TRUE,$E$12*0.1,E7*0.52))","v":10}]
[null,null,"PM2,5",null,100,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"  "]
[]
[null,true]
[null,null,null,null,{"$f":"IF(B14=TRUE,$E$16*0.1,0)","v":15},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null," "]
[null,null,"NO2",null,150]
[null,true]
[]
[]
[null,"Aandeel ziektelast als % van het totaal aantal gevallen (b.v. van alle gevallen van longkanker per jaar wordt x% veroorzaakt door luchtverontreiniging)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Indicator","Ziektelast",null,null,null,null,"Cases per jaar"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PM2,5","Laag geboortegewicht (0-1)",null,null,null,null,{"$f":"Rekenmodel!E8","v":26.776145162124713}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"NO2","Incidentie astma kinderen (0-18)",null,null,null,null,{"$f":"Rekenmodel!E9","v":259.21513663852033}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PM2,5","Incidentie hartinfarct (35+)",null,null,null,null,{"$f":"Rekenmodel!E10","v":723.39067887798774}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PM2,5","Incidentie beroerte (35+)",null,null,null,null,{"$f":"Rekenmodel!E11","v":847.99448136558931}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PM2,5","Longkanker (50+)",null,null,null,null,{"$f":"Rekenmodel!E12","v":217.80658676998488}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PM2,5","Ziekenhuisopnames astma (alle leeftijden)",null,null,null,null,{"$f":"Rekenmodel!E13","v":22.645958369666044}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"PM2,5","Ziekenhuisopnames COPD (alle leeftijden)",null,null,null,null,{"$f":"Rekenmodel!E14","v":60.00803736678867}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"NO2","Ziekenhuisopnames astma (alle leeftijden)",null,null,null,null,{"$f":"Rekenmodel!E15","v":20.788096558676138}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"NO2","Ziekenhuisopnames ischemische hartziekten (40+)",null,null,null,null,{"$f":"Rekenmodel!E16","v":116.45845983007651}]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Aantal meegerookte sigaretten per dag (op basis van PM2,5 en NO2)"]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"ROUND(Meerookmethode!G9,1)","v":4.2}]

{"sheet":"Rekenblad","index":2,"n_rows":40,"n_cols":3,"rows_kept":40,"cut":false,"hidden":true,"merged":[]}
["GEEL=VERWIJZING INVULBLAD EN RESULTATEN",2021]
["GROEN=RESULTATEN ZIEKTELAST"]
["ORANJE=RESULTATEN VROEGTIJDIG OVERLIJDEN"]
[]
["Totaal aantal inwoners waarop de berekening betrekking heeft",{"$f":"'Invulblad en resultaten'!E3","v":"2013438"},"Bevolking 2021"]
["Welk verschil in PM10 concentratie wil je doorrekenen?",{"$f":"'Invulblad en resultaten'!E7","v":15},"Bevolkingsgewogen gemiddelde "]
["Welk verschil in PM2,5 concentratie wil je doorrekenen? ",{"$f":"'Invulblad en resultaten'!E11","v":10},"Bevolkingsgewogen gemiddelde "]
["Op welk verschil in NO2 concentratie heeft de berekening van levensduur betrekking? ",{"$f":"'Invulblad en resultaten'!E15","v":15},"Bevolkingsgewogen gemiddelde "]
[]
[]
["Ziektelast","Attributieve cases / ziektelast *","Aandeel ziektelast door PM2,5 **"]
["Laag geboortegewicht (0-1) - PM2,5",{"$f":"Rekenmodel!E8","v":26.776145162124713},{"$f":"Rekenmodel!F8","v":7.4930619796484702E-2}]
["Incidentie astma kinderen (0-18) - NO2",{"$f":"Rekenmodel!E9","v":259.21513663852033},{"$f":"Rekenmodel!F9","v":0.16639734895460012}]
["Incidentie hartinfarct (35+) - PM2,5",{"$f":"Rekenmodel!E10","v":723.39067887798774},{"$f":"Rekenmodel!F10","v":9.0909090909090981E-2}]
["Incidentie beroerte (35+) - PM2,5",{"$f":"Rekenmodel!E11","v":847.99448136558931},{"$f":"Rekenmodel!F11","v":0.18699186991869918}]
["Longkanker (50+) - PM2,5",{"$f":"Rekenmodel!E12","v":217.80658676998488},{"$f":"Rekenmodel!F12","v":0.13793103448275856}]
["Ziekenhuisopnames astma (alle leeftijden) - PM2,5",{"$f":"Rekenmodel!E13","v":22.645958369666044},{"$f":"Rekenmodel!F13","v":2.24828934506353E-2}]
["Ziekenhuisopnames COPD (alle leeftijden) - PM2,5",{"$f":"Rekenmodel!E14","v":60.00803736678867},{"$f":"Rekenmodel!F14","v":2.4390243902438939E-2}]
["Ziekenhuisopnames astma (alle leeftijden) - NO2",{"$f":"Rekenmodel!E15","v":20.788096558676138},{"$f":"Rekenmodel!F15","v":2.0638409394776534E-2}]
["Ziekenhuisopnames ischemische hartziekten (40+) - NO2",{"$f":"Rekenmodel!E16","v":116.45845983007651},{"$f":"Rekenmodel!F16","v":1.7733729634950353E-2}]
[]
["*) Absoluut aantal gevallen door luchtverontreiniging, bijvoorbeeld een x aantal mensen per jaar met longkanker door luchtverontreiniging"]
["**) Percentage van het totaal aantal gevallen, bijvoorbeeld van alle gevallen longkanker per jaar wordt x procent veroorzaakt door luchtverontreiniging"]
[]
[null,"Percentage afname FEV1"]
["FEV1 daling kinderen (0-18 jaar) in procenten - PM2,5",{"$f":"Rekenmodel!E19","v":1.6E-2}]
["FEV1 daling kinderen (0-18 jaar) in procenten - NO2",{"$f":"Rekenmodel!E20","v":1.0500000000000001E-2}]
[]
["Vroegtijdig overlijden","Vroegtijdig overlijden"]
["Vroegtijdig overlijden two pollutant model:"]
["Vroegtijdig overlijden (totale sterfte) >30 jaar in dagen door PM2,5 en NO2",{"$f":"ROUND(Rekenmodel!E25,0)","v":351}]
[]
["Vroegtijdig overlijden one pollutant model (als je geen PM10/2,5 én NO2 concentraties hebt):"]
["Zie voor toelichting in begeleidende rapportage welke component je in jouw geval kunt gebruiken"]
["Vroegtijdig overlijden (totale sterfte) >30 jaar in dagen door PM10",{"$f":"ROUND(Rekenmodel!E28,0)","v":189}]
["Vroegtijdig overlijden (totale sterfte) >30 jaar in dagen door PM2,5",{"$f":"ROUND(Rekenmodel!E29,0)","v":369}]
["Vroegtijdig overlijden (totale sterfte) >30 jaar in dagen door NO2",{"$f":"ROUND(Rekenmodel!E30,0)","v":218}]
[]
[]
["Let op: Je mag in geen geval het vroegtijdig overlijden (in dagen) van bovenstaande berekeningen bij elkaar optellen. Je moet kiezen uit één van de getallen in de oranje vakjes"]

{"sheet":"Rekenmodel","index":3,"n_rows":30,"n_cols":24,"rows_kept":30,"cut":false,"hidden":true,"merged":[]}
[]
["Totaal aantal inwoners waarop de berekening betrekking heeft",{"$f":"'Invulblad en resultaten'!E3","v":"2013438"}]
["Welk verschil in PM10 concentratie wil je doorrekenen?",{"$f":"IF(Rekenblad!B6=\"\",\"\",Rekenblad!B6)","v":15}]
["Welk verschil in PM2.5 concentratie wil je doorrekenen? ",{"$f":"IF(Rekenblad!B7=\"\",\"\",Rekenblad!B7)","v":10}]
[{"$f":"IF(Rekenblad!A8=\"\",\"\",Rekenblad!A8)","v":"Op welk verschil in NO2 concentratie heeft de berekening van levensduur betrekking? "},{"$f":"IF(Rekenblad!B8=\"\",\"\",Rekenblad!B8)","v":15}]
[]
["Ziektelast",null,"Populatie at risk","Incidentie gekozen populatie","Attributieve cases / ziektelast ","Aandeel ziektelast door PM10/PM2.5/NO2",null,"RR voor PM10 (per 10 ug/m3)","RR voor PM2.5 (per 10 ug/m3)","RR voor NO2 (per 10 ug/m3)","beta per 1 ug/m3 PM2.5","beta voor 1 ug/m3 PM10","beta voor 1 ug/m3 NO2","RR behorend bij delta PM2.5 ","RR behorend bij delta NO2","RR behorend bij delta PM10","Attributieve cases door PM2.5","Attributieve cases door NO2",null,"Attributieve cases door PM10","Bron effectschatting","Incidentie/prevalentie 2019",null,"Bron incidentie/prevalentie"]
["Laag geboortegewicht (0-1)","PM2.5",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*'Leeftijdsopbouw NL 2021'!B5","v":20503.661784723176},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W8","v":357.34583852168925},{"$f":"Q8","v":26.776145162124713},{"$f":"E8/D8","v":7.4930619796484702E-2},null,null,1.081,null,{"$f":"LN(I8)/10","v":7.7886538657071193E-3},null,null,{"$f":"IF($B$4=\"\",\"\",EXP($B$4*$K8))","v":1.081},null,null,{"$f":"((N8-1)/N8)*$D8","v":26.776145162124713},null,null,null,"Li et al., 2020","Incidentie (0-1 jarigen)",3122,"RIVM-VTV, data 2021"]
["Incidentie astma kinderen (0-18)","NO2",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$5:$B$25)","v":453723.22445282363},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W9","v":1557.8080916976908},{"$f":"R9","v":259.21513663852033},0.16639734895460012,null,null,null,1.129,null,null,{"$f":"LN(J9)/10","v":1.2133228516752496E-2},null,{"$f":"IF($B$5=\"\",\"\",EXP($B$5*M9))","v":1.1996123077894791},null,null,{"$f":"((O9-1)/O9)*D9","v":259.21513663852033},null,null,"Khreis, H. et al, 2017","Incidentie  (0-20 jarigen)",13610,"RIVM-VTV, data 2021"]
["Incidentie hartinfarct volwassenen (35+)","PM2.5",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!B40:B104)","v":1194623.0481945204},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W10","v":7957.2974676578588},{"$f":"Q10","v":723.39067887798774},9.0909090909090981E-2,null,null,1.1000000000000001,null,{"$f":"LN(I10)/10","v":9.5310179804324931E-3},null,null,{"$f":"IF($B$4=\"\",\"\",EXP($B$4*$K10))","v":1.1000000000000001},null,null,{"$f":"((N10-1)/N10)*$D10","v":723.39067887798774},null,null,null,"Zhu et al., 2021","Incidentie (35+)",69520,"RIVM-VTV, data 2021"]
["Incidentie beroerte volwassenen (35+)","PM2,5",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!B40:B104)","v":1194623.0481945204},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W11","v":4534.927009042065},{"$f":"Q11","v":847.99448136558931},{"$f":"E11/D11","v":0.18699186991869918},null,null,1.23,null,{"$f":"LN(I11)/10","v":2.0701416938432613E-2},null,null,{"$f":"IF($B$4=\"\",\"\",EXP($B$4*$K11))","v":1.23},null,null,{"$f":"((N11-1)/N11)*$D11","v":847.99448136558931},null,null,null,"Yuan et al., 2019","Incidentie (35+)",39620,"RIVM-VTV, data 2021"]
["Longkanker (50+)","PM2.5",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!B55:B104)","v":827837.41915567522},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W12","v":1579.097754082391},{"$f":"Q12","v":217.80658676998488},{"$f":"E12/D12","v":0.13793103448275856},null,null,1.1599999999999999,null,{"$f":"LN(I12)/10","v":1.4842000511827321E-2},null,null,{"$f":"IF($B$4=\"\",\"\",EXP($B$4*$K12))","v":1.1599999999999999},null,null,{"$f":"((N12-1)/N12)*$D12","v":217.80658676998488},null,null,null,"Cibattini et al., 2020","Incidentie (50+)",13796,"RIVM-VTV, data 2021"]
["Ziekenhuisopnames astma (alle leeftijden) ","PM2.5",{"$f":"$B$2","v":"2013438"},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W13","v":1007.2528440073239},{"$f":"Q13","v":22.645958369666044},2.24828934506353E-2,null,null,1.0229999999999999,null,{"$f":"LN(I13)/10","v":2.2739486969489339E-3},null,null,{"$f":"IF($B$4=\"\",\"\",EXP($B$4*$K13))","v":1.0229999999999999},null,null,{"$f":"((N13-1)/N13)*$D13","v":22.645958369666044},null,null,null,"Zheng et al., 2015","Incidentie (alle leeftijden)",8800,"CBS Staline, VTV indeling, astma, data 2021"]
["Ziekenhuisopnames COPD (alle leeftijden)","PM2.5",{"$f":"$B$2","v":"2013438"},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W14","v":2460.329532038344},{"$f":"Q14","v":60.00803736678867},2.4390243902438939E-2,null,null,1.0249999999999999,null,{"$f":"LN(I14)/10","v":2.4692612590371415E-3},null,null,{"$f":"IF($B$4=\"\",\"\",EXP($B$4*$K14))","v":1.0249999999999999},null,null,{"$f":"((N14-1)/N14)*$D14","v":60.00803736678867},null,null,null,"Zhu et al., 2020","Incidentie (alle leeftijden)",21495,"CBS Staline, VTV indeling, COPD, data 2021"]
["Ziekenhuisopnames astma (alle leeftijden) ","NO2",{"$f":"$B$2","v":"2013438"},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W15","v":1007.2528440073239},{"$f":"R15","v":20.788096558676138},2.0638409394776534E-2,null,null,null,1.014,null,null,{"$f":"LN(J15)/10","v":1.3902905168991435E-3},null,{"$f":"IF($B$5=\"\",\"\",EXP($B$5*M15))","v":1.0210733293941234},null,null,{"$f":"((O15-1)/O15)*D15","v":20.788096558676138},null,null,"Zheng et al., 2021","Incidentie (alle leeftijden)",8800,"CBS Staline, VTV indeling, astma, data 2021"]
["Ziekenhuisopnames ischemische hartziekten (40+)","NO2",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!B45:B104)","v":1071924.6574623187},{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*W16","v":6567.0596218268411},{"$f":"R16","v":116.45845983007651},1.7733729634950353E-2,null,null,null,1.012,null,null,{"$f":"LN(J16)/10","v":1.1928570865273813E-3},null,{"$f":"IF($B$5=\"\",\"\",EXP($B$5*M16))","v":1.0180538924831042},null,null,{"$f":"((O16-1)/O16)*D16","v":116.45845983007651},null,null,"Stieb et al., 2020","Incidentie (45+)",57374,"Hartstichting 2022, data 2021"]
[]
[null,null,"Populatie at risk",null,"Percentage afname FEV1",null,null,null,"Daling in FEV1 voor PM2,5 (per 10 µg/m³)",null,null,null,null,null,null,null,null,null,null,null,"idem","idem",null,"idem"]
["FEV1 daling kinderen (0-18 jaar) in procenten","PM2.5",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$5:$B$25)","v":453723.22445282363},null,{"$f":"IF($B$4=\"\",\"\",(I19/10)*$B$4)","v":1.6E-2},null,null,null,1.6E-2,null,null,null,null,null,null,null,null,null,null,null,"Gehring, 2021","1,6% daling per 10 µg/m³ PM2,5",null,"nvt"]
["FEV1 daling kinderen (0-18 jaar) in procenten","NO2",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$5:$B$25)","v":453723.22445282363},null,{"$f":"IF($B$4=\"\",\"\",(J20/10)*$B$5)","v":1.0500000000000001E-2},null,null,null,null,7.0000000000000001E-3,null,null,null,null,null,null,null,null,null,null,"Gehring, 2021","0,7% daling per 10 µg/m³ NO2",null,"nvt"]
["Vroegtijdig overlijden",null,"Populatie at risk",null,"Vroegtijdig overlijden",null,null,"Aantal dagen vroegtijdig overlijden (per 10µg/m³)"]
["Vroegtijdig overlijden two pollutant model coform Hoffman/RIVM (2023):"]
["Totale sterfte (afname in levensverwachting) >30 jaar in dagen door PM2,5 ","PM2,5",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$35:$B$104)","v":1326078.5867209621},null,{"$f":"(H23/10)*$B$4","v":201},null,null,201,null,null,null,null,null,null,null,null,null,null,null,null,"Hoffman et al. 2022 & COMEAP 2018","Bevolking 30 jaar en ouder"]
["Totale sterfte (afname in levensverwachting) >30 jaar in dagen door NO2","NO2",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$35:$B$104)","v":1326078.5867209621},null,{"$f":"IF($B$5=\"\",\"\",(H24/10)*$B$5)","v":150},null,null,100,null,null,null,null,null,null,null,null,null,null,null,null,"Hoffman et al. 2022 & COMEAP 2018","Bevolking 30 jaar en ouder"]
["Totale sterfte (afname in levensverwachting) >30 jaar in dagen door PM2,5 en NO2 (two-pollutant model)","PM2,5 en NO2",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$35:$B$104)","v":1326078.5867209621},null,{"$f":"E23+E24","v":351},null,null,{"$f":"H23+H24","v":301},null,null,null,null,null,null,null,null,null,null,null,null,"Hoffman et al. 2022 & COMEAP 2018","Bevolking 30 jaar en ouder"]
[]
["Vroegtijdig overlijden one pollutant model (als je geen PM10/2,5 én NO2 concentraties hebt):"]
["Totale sterfte (afname in levensverwachting) >30 jaar in dagen door PM10 (one pollutant model - Hoek)","PM10",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$35:$B$104)","v":1326078.5867209621},null,{"$f":"(B3/10)*H28","v":189},null,null,126,null,null,null,null,null,null,null,null,null,null,null,null,"Cheng & Hoek, 2020","Bevolking 30 jaar en ouder"]
["Totale sterfte (afname in levensverwachting) >30 jaar in dagen door PM2,5 (one pollutant model - Hoffman)","PM2,5",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$35:$B$104)","v":1326078.5867209621},null,{"$f":"(B4/10)*H29","v":369},null,null,369,null,null,null,null,null,null,null,null,null,null,null,null,"Hoffman et al. 2022","Bevolking 30 jaar en ouder"]
["Totale sterfte (afname in levensverwachting) >30 jaar in dagen door NO2 (one pollutant model - Hoffman)","NO2",{"$f":"($B$2/'Leeftijdsopbouw NL 2021'!B4)*SUM('Leeftijdsopbouw NL 2021'!$B$35:$B$104)","v":1326078.5867209621},null,{"$f":"(B5/10)*H30","v":217.5},null,null,145,null,null,null,null,null,null,null,null,null,null,null,null,"Hoffman et al. 2022","Bevolking 30 jaar en ouder"]

{"sheet":"Leeftijdsopbouw NL 2021","index":4,"n_rows":104,"n_cols":5,"rows_kept":104,"cut":false,"hidden":true,"merged":[[1,6,1,7]]}
["Bevolking; geslacht en leeftijd op 1 januari 2022"]
["Statline"]
["2022-01-01"]
["Totaal M+V",17590672]
["0 jaar",179133,null,"0-4",{"$f":"SUM(B5:B9)","v":864653}]
["1 jaar",169323,null,"5-9",{"$f":"SUM(B10:B14)","v":894620}]
["2 jaar",171226,null,"10-14",{"$f":"SUM(B15:B19)","v":953188}]
["3 jaar",171415,null,"15-19",{"$f":"SUM(B20:B24)","v":1025356}]
["4 jaar",173556]
["5 jaar",176741]
["6 jaar",176234]
["7 jaar",181103]
["8 jaar",177793]
["9 jaar",182749]
["10 jaar",186513]
["11 jaar",191599]
["12 jaar",192560]
["13 jaar",193037]
["14 jaar",189479]
["15 jaar",192725]
["16 jaar",194719]
["17 jaar",200939]
["18 jaar",214061]
["19 jaar",222912]
["20 jaar",226197]
["21 jaar",231493]
["22 jaar",227225]
["23 jaar",226996]
["24 jaar",220974]
["25 jaar",220818]
["26 jaar",222029]
["27 jaar",229261]
["28 jaar",229982]
["29 jaar",232416]
["30 jaar",235174]
["31 jaar",235817]
["32 jaar",227912]
["33 jaar",225299]
["34 jaar",224277]
["35 jaar",223383]
["36 jaar",217872]
["37 jaar",214114]
["38 jaar",208001]
["39 jaar",208601]
["40 jaar",211882]
["41 jaar",214516]
["42 jaar",207041]
["43 jaar",206855]
["44 jaar",203753]
["45 jaar",205223]
["46 jaar",206214]
["47 jaar",215171]
["48 jaar",222245]
["49 jaar",239601]
["50 jaar",250796]
["51 jaar",260912]
["52 jaar",265900]
["53 jaar",254354]
["54 jaar",251108]
["55 jaar",251762]
["56 jaar",254567]
["57 jaar",258325]
["58 jaar",253240]
["59 jaar",247599]
["60 jaar",243990]
["61 jaar",236460]
["62 jaar",232975]
["63 jaar",225583]
["64 jaar",219489]
["65 jaar",214114]
["66 jaar",207190]
["67 jaar",202404]
["68 jaar",197548]
["69 jaar",196060]
["70 jaar",187009]
["71 jaar",185993]
["72 jaar",185630]
["73 jaar",188339]
["74 jaar",194454]
["75 jaar",196590]
["76 jaar",136563]
["77 jaar",138728]
["78 jaar",127888]
["79 jaar",113836]
["80 jaar",104107]
["81 jaar",101553]
["82 jaar",92671]
["83 jaar",85237]
["84 jaar",73972]
["85 jaar",67067]
["86 jaar",59420]
["87 jaar",52155]
["88 jaar",44428]
["89 jaar",38948]
["90 jaar",32086]
["91 jaar",26672]
["92 jaar",20250]
["93 jaar",16003]
["94 jaar",11729]
["95 jaar",8822]
["96 jaar",6229]
["97 jaar",4356]
["98 jaar",2895]
["99 jaar of ouder",4507]

{"sheet":"Meerookmethode","index":5,"n_rows":45,"n_cols":23,"rows_kept":45,"cut":false,"hidden":true,"merged":[]}
[null,null,null,null,null,"component","schatting aantal meegerookte sigaretten","standaard error van schatting aantal meegerookte sigaretten",null,null,null,"number of pollutants available for comparison","se to usein calculation combined se"]
[null,"VUL DE CONCENTRATIEVERSCHILLEN IN IN DE CELLEN D5, D6. D7 ",null,null,null,"NO2",{"$f":"IF($D$5=\"\",\"\",AVERAGE(S11:S20))","v":3.293335539488909},{"$f":"IF($D$5=\"\",\"\",SQRT(1/16*($T$11^2+$T$14^2+$T$17^2+$T$20^2)))","v":0.58910886133604823},null,null,null,{"$f":"COUNT(G2:G6)","v":2},{"$f":"IF(H2=\"\", \"0\",H2)","v":0.58910886133604823}]
[null,"(LAAT LEEG ALS JE GEEN GEGEVENS HEBT)"]
[null,null,null,null,null,"EC",{"$f":"IF($D$6=\"\",\"\",AVERAGE(S23:S32))","v":""},{"$f":"IF($D$6=\"\",\"\",SQRT(1/16*($T$23^2+$T$26^2+$T$29^2+$T$32^2)))","v":""},null,null,null,null,{"$f":"IF(H4=\"\", \"0\",H4)","v":"0"}]
[null,"verschil in concentratie (µg/m3)","NO2",{"$f":"Rekenblad!B8","v":15}]
[null,null,null,null,null,"PM2.5",{"$f":"IF($D$7=\"\",\"\",AVERAGE(S35:S44))","v":5.1212810578608501},{"$f":"IF($D$7=\"\",\"\",SQRT(1/16*($T$35^2+$T$38^2+$T$41^2+$T$44^2)))","v":0.86213854654841549},null,null,null,null,{"$f":"IF(H6=\"\", \"0\",H6)","v":0.86213854654841549}]
[null,null,"PM2.5",{"$f":"Rekenblad!B7","v":10}]
[null,null,null,null,null,"overall",{"$f":"AVERAGE($G$2:$G$6)","v":4.2073082986748798},{"$f":"SQRT(1/($L2^2)*($M$2^2+$M$4^2+$M$6^2))","v":0.52209484865043188}]
[null,null,null,null,null,"NO2 en PM2.5",{"$f":"AVERAGE(G2,G6)","v":4.2073082986748798}]
[null,"Blootstelling","Relatief Risico / regressiecoefficient","ondergrens 95% btbhti","bovengrens 95% btbhi","Toename in concentratie (ug/m3) waarop RR / regressiecoefficient voor luvo gebaseerd is:","Aantal meegerookte sigaretten waarop de risicoschatting gebaseerd is:","regressiecoefficient per 1 ug/m3 toename in concentratie","ondergrens 95% btbhi van regressiecoefficient per 1 ug/m3 toename in concentratie","bovengrens 95% btbhi van regressiecoefficient per 1 ug/m3 toename in concentratie","standaard error van regressiecoefficient per 1 ug/m3","regressiecoefficient per meegerookte sigaret","ondergrens 95% btbhi van regressiecoefficient per meegerookte sigaret","bovengrens 95% btbhi van regressiecoefficient per meegerookte sigaret","standaarderror van de regressiecoefficient per meegerookte sigaret","Ratio X/Y (regressie coeff per 1 ug/m3 luvo/regressie coeff per sig)","Gecombineerde standaard error van de Ratio R","veandering in concentratie (µg/m3) (WORDT STANDAARD OVERGENOMEN UIT CEL D5)","Equivalent aantal meegerookte sigaretten","standaarderror van equivalent aantal meegerookte sigaretten","2* standard error","ondergrens (95% btbhi) aantal meegerookte sigaretten","bovengrens (95% btbhi) aantal meegerookte sigaretten"]
["Laag geboortegewicht","NO2",1.016,1,1.03,10,null,{"$f":"LN(C11)/F11","v":1.5873349156290163E-3},{"$f":"LN(D11)/F11","v":0},{"$f":"LN(E11)/F11","v":2.955880224154443E-3},{"$f":"($J11-$H11)/1.96","v":6.9823740230889116E-4},null,null,null,null,{"$f":"H11/L12","v":3.449833486678866E-2},{"$f":"P11*SQRT((K11/H11)^2+(O12/L12)^2)","v":1.878619577424339E-2},{"$f":"IF($D$5=\"\",\"\",$D$5)","v":15},{"$f":"IF(R11=\"\",\"\",R11*P11)","v":0.5174750230018299},{"$f":"IF(R11=\"\",\"\",R11*Q11)","v":0.28179293661365085},{"$f":"IF(R11=\"\",\"\",R11*1.96*Q11)","v":0.55231415576275567},{"$f":"IF(R11=\"\",\"\",S11-U11)","v":-3.4839132760925762E-2},{"$f":"IF(R11=\"\",\"\",S11+U11)","v":1.0697891787645855}]
["Laag geboortegewicht","ETS blootstelling ('meeroken') ",1.38,1.1299999999999999,1.69,null,7,null,null,null,null,{"$f":"LN(C12)/G12","v":4.6011928452730458E-2},{"$f":"LN(D12)/G12","v":1.7459661817749873E-2},{"$f":"LN(E12)/G12","v":7.496121841928316E-2},{"$f":"(N12-L12)/1.96","v":1.47700459013024E-2}]
[]
["Afname in longfunctie  (FEV1) bij kinderen (%)","NO2",0.7,0.4,1,10,null,{"$f":"C14/F14","v":6.9999999999999993E-2},{"$f":"$D14/$F14","v":0.04},{"$f":"$E14/$F14","v":0.1},{"$f":"($J14-$H14)/1.96","v":1.5306122448979598E-2},null,null,null,null,{"$f":"H14/L15","v":0.44999999999999996},{"$f":"P14*SQRT((K14/H14)^2+(O15/L15)^2)","v":0.12808354060342544},{"$f":"IF($D$5=\"\",\"\",$D$5)","v":15},{"$f":"IF(R14=\"\",\"\",R14*P14)","v":6.7499999999999991},{"$f":"IF(R14=\"\",\"\",R14*Q14)","v":1.9212531090513816},{"$f":"IF(R14=\"\",\"\",R14*1.96*Q14)","v":3.765656093740708},{"$f":"IF(R14=\"\",\"\",S14-U14)","v":2.9843439062592911},{"$f":"IF(R14=\"\",\"\",S14+U14)","v":10.515656093740708}]
["Afname in longfunctie  (FEV1) bij kinderen (%)","ETS blootstelling ('meeroken') ",1.4,1,1.9,null,9,null,null,null,null,{"$f":"C15/G15","v":0.15555555555555556},{"$f":"D15/G15","v":0.1111111111111111},{"$f":"E15/G15","v":0.21111111111111111},{"$f":"(N15-L15)/1.96","v":2.8344671201814057E-2}]
[]
["Sterfte aan hart-en vaatziekten","NO2",1.089,1.06,1.1200000000000001,10,null,{"$f":"LN(C17)/F17","v":8.5259843950823387E-3},{"$f":"LN($D17)/$F17","v":5.8268908123975827E-3},{"$f":"LN($E17)/$F17","v":1.1332868530700327E-2},{"$f":"(J17-H17)/1.96","v":1.4320837426622388E-3},null,null,null,null,{"$f":"H17/L18","v":0.24969736720748106},{"$f":"P17*SQRT((K17/H17)^2+(O18/L18)^2)","v":5.559510994509325E-2},{"$f":"IF($D$5=\"\",\"\",$D$5)","v":15},{"$f":"IF(R17=\"\",\"\",R17*P17)","v":3.7454605081122159},{"$f":"IF(R17=\"\",\"\",R17*Q17)","v":0.8339266491763988},{"$f":"IF(R17=\"\",\"\",R17*1.96*Q17)","v":1.6344962323857415},{"$f":"IF(R17=\"\",\"\",S17-U17)","v":2.1109642757264746},{"$f":"IF(R17=\"\",\"\",S17+U17)","v":5.3799567404979571}]
["Sterfte aan hart-en vaatziekten","ETS blootstelling ('meeroken') ",1.27,1.19,1.36,null,7,null,null,null,null,{"$f":"LN(C18)/G18","v":3.4145271495785702E-2},{"$f":"LN(D18)/G18","v":2.4850472446205425E-2},{"$f":"LN(E18)/G18","v":4.3926385678280104E-2},{"$f":"(N18-L18)/1.96","v":4.9903643788236744E-3}]
[]
["Longkanker","NO2",1.04,1.01,1.0760000000000001,10,null,{"$f":"LN(C20)/F20","v":3.9220713153281326E-3},{"$f":"LN($D20)/$F20","v":9.9503308531680916E-4},{"$f":"LN($E20)/$F20","v":7.3250461739592741E-3},{"$f":"(J20-H20)/1.96","v":1.736211662566909E-3},null,null,null,null,{"$f":"H20/L21","v":0.14402710845610606},{"$f":"P20*SQRT((K20/H20)^2+(O21/L21)^2)","v":6.9497676498425726E-2},{"$f":"IF($D$5=\"\",\"\",$D$5)","v":15},{"$f":"IF(R20=\"\",\"\",R20*P20)","v":2.1604066268415907},{"$f":"IF(R20=\"\",\"\",R20*Q20)","v":1.042465147476386},{"$f":"IF(R20=\"\",\"\",R20*1.96*Q20)","v":2.0432316890537163},{"$f":"IF(R20=\"\",\"\",S20-U20)","v":0.11717493778787436},{"$f":"IF(R20=\"\",\"\",S20+U20)","v":4.203638315895307}]
["Longkanker","ETS blootstelling ('meeroken') ",1.21,1.1299999999999999,1.3,null,7,null,null,null,null,{"$f":"LN(C21)/G21","v":2.7231479944092814E-2},{"$f":"LN(D21)/G21","v":1.7459661817749873E-2},{"$f":"LN(E21)/G21","v":3.748060920964158E-2},{"$f":"(N21-L21)/1.96","v":5.2291475844636563E-3}]
[]
["Laag geboortegewicht","Roet",1,1,1,1,null,{"$f":"LN(C23)/F23","v":0},{"$f":"LN($D23)/$F23","v":0},{"$f":"LN($E23)/$F23","v":0},{"$f":"($J23-$H23)/1.96","v":0},null,null,null,null,{"$f":"H23/L24","v":0},{"$f":"P23*SQRT((K23/H23)^2+(O24/L24)^2)","v":{"$error":"#DIV/0!"}},{"$f":"IF($D$6=\"\",\"\",$D$6)","v":""},{"$f":"IF(R23=\"\",\"\",R23*P23)","v":""},{"$f":"IF(R23=\"\",\"\",R23*Q23)","v":""},{"$f":"IF(R23=\"\",\"\",R23*1.96*Q23)","v":""},{"$f":"IF(R23=\"\",\"\",S23-U23)","v":""},{"$f":"IF(R23=\"\",\"\",S23+U23)","v":""}]
["Laag geboortegewicht","ETS blootstelling ('meeroken') ",1.38,1.1299999999999999,1.69,null,7,null,null,null,null,{"$f":"LN(C24)/G24","v":4.6011928452730458E-2},{"$f":"LN(D24)/G24","v":1.7459661817749873E-2},{"$f":"LN(E24)/G24","v":7.496121841928316E-2},{"$f":"(N24-L24)/1.96","v":1.47700459013024E-2}]
[]
["Afname in longfunctie  (FEV1) bij kinderen (%)","Roet",1,1,1,1,null,{"$f":"C26/F26","v":1},{"$f":"$D26/$F26","v":1},{"$f":"$E26/$F26","v":1},{"$f":"($J26-$H26)/1.96","v":0},null,null,null,null,{"$f":"H26/L27","v":6.4285714285714288},{"$f":"P26*SQRT((K26/H26)^2+(O27/L27)^2)","v":1.1713869221157851},{"$f":"IF($D$6=\"\",\"\",$D$6)","v":""},{"$f":"IF(R26=\"\",\"\",R26*P26)","v":""},{"$f":"IF(R26=\"\",\"\",R26*Q26)","v":""},{"$f":"IF(R26=\"\",\"\",R26*1.96*Q26)","v":""},{"$f":"IF(R26=\"\",\"\",S26-U26)","v":""},{"$f":"IF(R26=\"\",\"\",S26+U26)","v":""}]
["Afname in longfunctie  (FEV1) bij kinderen (%)","ETS blootstelling ('meeroken') ",1.4,1,1.9,null,9,null,null,null,null,{"$f":"C27/G27","v":0.15555555555555556},{"$f":"D27/G27","v":0.1111111111111111},{"$f":"E27/G27","v":0.21111111111111111},{"$f":"(N27-L27)/1.96","v":2.8344671201814057E-2}]
[]
["Sterfte aan hart-en vaatziekten","Roet",1,1,1,1,null,{"$f":"LN(C29)/F29","v":0},{"$f":"LN($D29)/$F29","v":0},{"$f":"LN($E29)/$F29","v":0},{"$f":"($J29-$H29)/1.96","v":0},null,null,null,null,{"$f":"H29/L30","v":0},{"$f":"P29*SQRT((K29/H29)^2+(O30/L30)^2)","v":{"$error":"#DIV/0!"}},{"$f":"IF($D$6=\"\",\"\",$D$6)","v":""},{"$f":"IF(R29=\"\",\"\",R29*P29)","v":""},{"$f":"IF(R29=\"\",\"\",R29*Q29)","v":""},{"$f":"IF(R29=\"\",\"\",R29*1.96*Q29)","v":""},{"$f":"IF(R29=\"\",\"\",S29-U29)","v":""},{"$f":"IF(R29=\"\",\"\",S29+U29)","v":""}]
["Sterfte aan hart-en vaatziekten","ETS blootstelling ('meeroken') ",1.27,1.19,1.36,null,7,null,null,null,null,{"$f":"LN(C30)/G30","v":3.4145271495785702E-2},{"$f":"LN(D30)/G30","v":2.4850472446205425E-2},{"$f":"LN(E30)/G30","v":4.3926385678280104E-2},{"$f":"(N30-L30)/1.96","v":4.9903643788236744E-3}]
[]
["Longkanker","Roet",1,1,1,1,null,{"$f":"LN(C32)/F32","v":0},{"$f":"LN($D32)/$F32","v":0},{"$f":"LN($E32)/$F32","v":0},{"$f":"($J32-$H32)/1.96","v":0},null,null,null,null,{"$f":"H32/L33","v":0},{"$f":"P32*SQRT((K32/H32)^2+(O33/L33)^2)","v":{"$error":"#DIV/0!"}},{"$f":"IF($D$6=\"\",\"\",$D$6)","v":""},{"$f":"IF(R32=\"\",\"\",R32*P32)","v":""},{"$f":"IF(R32=\"\",\"\",R32*Q32)","v":""},{"$f":"IF(R32=\"\",\"\",R32*1.96*Q32)","v":""},{"$f":"IF(R32=\"\",\"\",S32-U32)","v":""},{"$f":"IF(R32=\"\",\"\",S32+U32)","v":""}]
["Longkanker","ETS blootstelling ('meeroken') ",1.21,1.1299999999999999,1.3,null,7,null,null,null,null,{"$f":"LN(C33)/G33","v":2.7231479944092814E-2},{"$f":"LN(D33)/G33","v":1.7459661817749873E-2},{"$f":"LN(E33)/G33","v":3.748060920964158E-2},{"$f":"(N33-L33)/1.96","v":5.2291475844636563E-3}]
[]
["Laag geboortegewicht","PM2.5",1.081,1.04,1.1200000000000001,10,null,{"$f":"LN(C35)/F35","v":7.7886538657071193E-3},{"$f":"LN($D35)/$F35","v":3.9220713153281326E-3},{"$f":"LN($E35)/$F35","v":1.1332868530700327E-2},{"$f":"($J35-$H35)/1.96","v":1.8082727882618407E-3},null,null,null,null,{"$f":"H35/L36","v":0.16927466697486185},{"$f":"P35*SQRT((K35/H35)^2+(O36/L36)^2)","v":6.7060505334716206E-2},{"$f":"IF($D$7=\"\",\"\",$D$7)","v":10},{"$f":"IF(R35=\"\",\"\",R35*P35)","v":1.6927466697486184},{"$f":"IF(R35=\"\",\"\",R35*Q35)","v":0.67060505334716203},{"$f":"IF(R35=\"\",\"\",R35*1.96*Q35)","v":1.3143859045604378},{"$f":"IF(R35=\"\",\"\",S35-U35)","v":0.37836076518818063},{"$f":"IF(R35=\"\",\"\",S35+U35)","v":3.0071325743090562}]
["Laag geboortegewicht","ETS blootstelling ('meeroken') ",1.38,1.1299999999999999,1.69,null,7,null,null,null,null,{"$f":"LN(C36)/G36","v":4.6011928452730458E-2},{"$f":"LN(D36)/G36","v":1.7459661817749873E-2},{"$f":"LN(E36)/G36","v":7.496121841928316E-2},{"$f":"(N36-L36)/1.96","v":1.47700459013024E-2}]
[]
["Afname in longfunctie  (FEV1) bij kinderen (%)","PM2.5",1.6,1,2.2999999999999998,10,null,{"$f":"C38/F38","v":0.16},{"$f":"$D38/$F38","v":0.1},{"$f":"$E38/$F38","v":0.22999999999999998},{"$f":"($J38-$H38)/1.96","v":3.5714285714285705E-2},null,null,null,null,{"$f":"H38/L39","v":1.0285714285714285},{"$f":"P38*SQRT((K38/H38)^2+(O39/L39)^2)","v":0.29637709580969634},{"$f":"IF($D$7=\"\",\"\",$D$7)","v":10},{"$f":"IF(R38=\"\",\"\",R38*P38)","v":10.285714285714285},{"$f":"IF(R38=\"\",\"\",R38*Q38)","v":2.9637709580969633},{"$f":"IF(R38=\"\",\"\",R38*1.96*Q38)","v":5.8089910778700489},{"$f":"IF(R38=\"\",\"\",S38-U38)","v":4.4767232078442358},{"$f":"IF(R38=\"\",\"\",S38+U38)","v":16.094705363584332}]
["Afname in longfunctie  (FEV1) bij kinderen (%)","ETS blootstelling ('meeroken') ",1.4,1,1.9,null,9,null,null,null,null,{"$f":"C39/G39","v":0.15555555555555556},{"$f":"D39/G39","v":0.1111111111111111},{"$f":"E39/G39","v":0.21111111111111111},{"$f":"(N39-L39)/1.96","v":2.8344671201814057E-2}]
[]
["Sterfte aan hart-en vaatziekten","PM2.5",1.1100000000000001,1.0900000000000001,1.1399999999999999,10,null,{"$f":"LN(C41)/F41","v":1.0436001532424286E-2},{"$f":"LN($D41)/$F41","v":8.6177696241052405E-3},{"$f":"LN($E41)/$F41","v":1.31028262406404E-2},{"$f":"($J41-$H41)/1.96","v":1.3606248511306704E-3},null,null,null,null,{"$f":"H41/L42","v":0.30563533617567878},{"$f":"P41*SQRT((K41/H41)^2+(O42/L42)^2)","v":5.98596957526056E-2},{"$f":"IF($D$7=\"\",\"\",$D$7)","v":10},{"$f":"IF(R41=\"\",\"\",R41*P41)","v":3.0563533617567877},{"$f":"IF(R41=\"\",\"\",R41*Q41)","v":0.59859695752605602},{"$f":"IF(R41=\"\",\"\",R41*1.96*Q41)","v":1.1732500367510699},{"$f":"IF(R41=\"\",\"\",S41-U41)","v":1.8831033250057179},{"$f":"IF(R41=\"\",\"\",S41+U41)","v":4.2296033985078578}]
["Sterfte aan hart-en vaatziekten","ETS blootstelling ('meeroken') ",1.27,1.19,1.36,null,7,null,null,null,null,{"$f":"LN(C42)/G42","v":3.4145271495785702E-2},{"$f":"LN(D42)/G42","v":2.4850472446205425E-2},{"$f":"LN(E42)/G42","v":4.3926385678280104E-2},{"$f":"(N42-L42)/1.96","v":4.9903643788236744E-3}]
[]
["Longkanker","PM2.5",1.1599999999999999,1.0900000000000001,1.23,10,null,{"$f":"LN(C44)/F44","v":1.4842000511827321E-2},{"$f":"LN($D44)/$F44","v":8.6177696241052405E-3},{"$f":"LN($E44)/$F44","v":2.0701416938432613E-2},{"$f":"($J44-$H44)/1.96","v":2.9894981768394347E-3},null,null,null,null,{"$f":"H44/L45","v":0.5450309914223711},{"$f":"P44*SQRT((K44/H44)^2+(O45/L45)^2)","v":0.15167591199398262},{"$f":"IF($D$7=\"\",\"\",$D$7)","v":10},{"$f":"IF(R44=\"\",\"\",R44*P44)","v":5.4503099142237108},{"$f":"IF(R44=\"\",\"\",R44*Q44)","v":1.516759119939826},{"$f":"IF(R44=\"\",\"\",R44*1.96*Q44)","v":2.9728478750820595},{"$f":"IF(R44=\"\",\"\",S44-U44)","v":2.4774620391416513},{"$f":"IF(R44=\"\",\"\",S44+U44)","v":8.4231577893057707}]
["Longkanker","ETS blootstelling ('meeroken') ",1.21,1.1299999999999999,1.3,null,7,null,null,null,null,{"$f":"LN(C45)/G45","v":2.7231479944092814E-2},{"$f":"LN(D45)/G45","v":1.7459661817749873E-2},{"$f":"LN(E45)/G45","v":3.748060920964158E-2},{"$f":"(N45-L45)/1.96","v":5.2291475844636563E-3}]